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International Journal of Plant Based Pharmaceuticals
e‑ISSN 2791-7509 Open Access · CC BY 4.0
Vol. 3 · Issue 2 · 2023 Jul 26, 2023 Research Articles

The effects of Quercus (Oak) acorn on cutaneous wound healing in rats

AU
Ahmet Uyar Corresponding Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Pathology, Hatay, Türkiye uyarahmet@hotmail.com Turkey
GJ
Gwlshan Mohammed Jhangir Yuzuncu Yil University, Faculty of Veterinary Medicine, Department of Pathology, Van, Türkiye Turkey
ÖK
Ömer Faruk Keleş Yuzuncu Yil University, Faculty of Veterinary Medicine, Department of Pathology, Van, Türkiye Turkey
ZY
Zabit Yener Yuzuncu Yil University, Faculty of Veterinary Medicine, Department of Pathology, Van, Türkiye Turkey
Pages148-155 PublishedJul 26, 2023 LicenseOpen Access
Full Text
IJPBP 2 VOL 3 · 2
VOL 3 · NO 2 · 2023 View issue

Abstract

Quercus spp. (Oak) has been used in traditional medicine due to its medicinal properties for centuries. However, its effect on wound healing in the skin is well unknown. This experimental trial was performed to evaluate in vivo wound healing of Oak acorn in the skin of rats. In the present trial, 24 Wistar albino rats were allocated to three groups equally, control ( n = 8), Madecassol® ( n = 8), and Oak acorn ( n = 8). The circular excision wound models by biopsy punch device were applied in the interscapular region in rats. Oak acorn and Madecassol® pomade have been applied to experimental groups per day and normal saline solution and glycerin have been given to the control group locally as placebo. Blood and skin tissue were collected to evaluate histopathological and biochemical alterations on days 7 th and 15 th . In comparison with the control group, the topical administration of Oak acorn showed definite effects on epithelization, proliferative impacts on fibroblast cells, and enhancing effect on collagen formation by reducing inflammation and edema. Biochemical investigations of skin and blood tissues exhibited that fluctuated malondialdehyde and antioxidant defense system components were rehabilitated in the Oak acorn group. This experimental study revealed that pomade obtained from the Oak acorn displays remarkable wound-healing activity.

Keywords

#Oak acorn #Epithelization #Wound healing #Rat

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Copyright (c) 2023 Ahmet Uyar, Gwlshan Mohammed Jhangir, Ömer Faruk Keleş, Zabit Yener

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