Effect of Nopalea cochenillifera (L.) Salm-Dyck cladodes flour on glucose levels in streptozotocin-induced diabetic CD-1 mice


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Authors

  • Héctor Enrique Fabela-Illescas Universidad Autónoma del Estado de Hidalgo, Instituto de Ciencias Agropecuarias, Av. Universidad Km 1, Rancho Universitario, C.P. 43600, Tulancingo de Bravo, Hidalgo, México https://orcid.org/0000-0003-4421-4409
  • Juan Pablo Hernández-Uribe Universidad Autónoma del Estado de Hidalgo, Instituto de Ciencias Agropecuarias, Av. Universidad Km 1, Rancho Universitario, C.P. 43600, Tulancingo de Bravo, Hidalgo, México https://orcid.org/0000-0002-2759-1192
  • Helen Belefant-Miller Dale Bumpers National Rice Research Center, Stuttgart, AR 72160, USA https://orcid.org/0000-0002-9847-8824
  • Mónica Alonso de Jesús Universidad Nacional Autónoma de México, Facultad de Medicina Veterinaria y Zootecnia Av. Universidad 3000, 04510, Ciudad de México, México https://orcid.org/0009-0009-5368-7487
  • Gabriel Betanzos-Cabrera Universidad Autónoma del Estado de Hidalgo, Instituto de Ciencias de la Salud, Área Académica de Nutrición, Ex-Hacienda de la Concepción, Tilcuautla, Pachuca de Soto 42080, Mexico https://orcid.org/0000-0003-2027-6904

DOI:

https://doi.org/10.29228/ijpbp.34

Keywords:

Cactus, Nopalea cochenillifera (L.) Salm-Dyck, Diabetes, Bioactive compounds, Diabetic mice

Abstract

Nopalea cochenillifera (L.) Salm-Dyck is a cactus species native to Mexico, now widely distributed in the West Indies and tropical America. It is a species not usually consumed as food, but due to its composition of bioactive compounds, it could be used to treat diabetes. The present study aimed to evaluate the effect of N. cochenillifera cladode flour on glucose levels in streptozotocin-induced diabetic CD-1 mice. The flour obtained from cladodes absorbed glucose proportionally to the glucose concentration, and it was observed that the administration of flour (10.5 mg/kg body) decreased glucose levels in diabetic mice compared to the control group. This preclinical study demonstrates that N. cochenillifera flour could be used to improve glucose homeostasis in type 2 diabetes.

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Published

14.10.2023

How to Cite

Fabela-Illescas, H. E., Hernández-Uribe, J. P., Belefant-Miller, H., de Jesús, M. A., & Betanzos-Cabrera, G. (2023). Effect of Nopalea cochenillifera (L.) Salm-Dyck cladodes flour on glucose levels in streptozotocin-induced diabetic CD-1 mice. International Journal of Plant Based Pharmaceuticals, 3(2), 210–214. https://doi.org/10.29228/ijpbp.34

Issue

Section

Short Report
Received 2023-07-10
Accepted 2023-10-08
Published 2023-10-14